Integrated genomic analysis reveals actionable targets in pediatric spinal cord low-grade gliomas
Abstract Gliomas are the most common central nervous tumors in children and adolescents.However, spinal cord low-grade gliomas (sLGGs) are rare, with scarce information on tumor genomics and epigenomics.To define the molecular landscape of sLGGs, we integrated clinical data, histology, and multi-level genetic and epigenetic analyses on a consecutiv